HCID 131711763, compound → HCID 14304405, compound

HRID 1395661Notes

Reaction equation

HRID 1395661 reaction equation
[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C:18]([NH:20][C@@H:21]([C:23]([NH2:25])=[O:24])[CH3:22])=[O:19])[CH2:3][C:4]1[CH:9]=[CH:8][C:7]([O:10]CC2C=CC=CC=2)=[CH:6][CH:5]=1>CO.C(O)(=O)C.[Pd]>[NH2:1][C@H:2]([C:18]([NH:20][C@@H:21]([C:23]([NH2:25])=[O:24])[CH3:22])=[O:19])[CH2:3][C:4]1[CH:5]=[CH:6][C:7]([OH:10])=[CH:8][CH:9]=1

Participants

5

Reactant 1

HCID 131711763HCID 131711763, compound

Product 1

HCID 14304405HCID 14304405, compound

Reagents, catalysts & solvents 3

HCID 176Acetic AcidCatalystHCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

1 G. of the product of Example 2 was hydrogenated in methanol at TR and 1 atmosphere with 600 mg. of 10% Pd. on carbon catalyst with a few drops of glacial acetic acid for 20 hours at TR. The catalyst was removed by filtration and the methanol evaporated to dryness in vacuo. The product was lyophyllized from water to yield 500 mg. of title compound.

Workup

  1. customThe catalyst was removed by filtration
  2. customthe methanol evaporated to dryness in vacuo
  3. customto yield 500 mg

Sources & evidence

ORD record
ord-4dabfbd34be145de96678fda24d2cf70
Source dataset
uspto-grants-1980_05
Patent number
US04205069

Reaction notes

Loading…