HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → H-D-Tyr-D-Ala-OMe
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | methyl D-alaninate | HCID 89020 | — |
| Reactant | (2R)-2-(((tert-butoxy)carbonyl)amino)-3-(4-hydroxyphenyl)propanoic acid | HCID 1549481 | — |
| Product | H-D-Tyr-D-Ala-OMe | HCID 131711764 | — |
Reaction Steps
t-Boc-D-Tyr-OH was coupled with D-Ala-OMe by the N-hydroxy-succinimide ester method (The Peptides, 1, p. 105). Deprotection was carried out using trifluoroacetic acid (The Peptides, 1, p. 39) and the resulting dipeptide methyl ester salt was purified by chromatography on Sephadex G-10 using 0.2 N HOAc.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04205069 |
| Source dataset | uspto-grants-1980_05 |
| ORD ID | ord-0efa0e861ab443f6b5fefde308e4517c |
| Source note | uspto-grants-1980_05 |