HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → HCID 131711765, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Benzhydrylamine | HCID 7036 | — |
| Reactant | Anisole | HCID 7519 | — |
| Reactant | Diisopropylcarbodiimide | HCID 12734 | — |
| Reactant | N-(tert-Butyloxycarbonyl)-D-methionine | HCID 111051 | — |
| Reactant | HCID 178418300 | HCID 178418300 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 131711765 | HCID 131711765 | — |
Reaction Steps
Prepared by solid phase using benzhydryl amine resin (14 g.) and t-Boc-D-Met-OH (10 g.) 5.4 g. hydroxybenzotriazole and 60 ml. DIC, deprotected with 30% TFA in MeCl2 and coupled with 18 g. t-Boc di Cl Bzl-Tyr-OH and 5.4 g. hydroxybenzotriazole and 6.0 ml. DIC. Deprotection with HF in the presence of 10 ml. anisole. The dipeptide was purified on Sephadex G-10 using 0.2 N HOAc.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04205069 |
| Source dataset | uspto-grants-1980_05 |
| ORD ID | ord-0fd1e6ed301f4c4da0a13ef1edf02fb1 |
| Source note | uspto-grants-1980_05 |