反应详情

A mixture of 1.3 g of Compound 1B and 50 ml of 10% alcoholic potassium hydroxide was refluxed for 4 hours. The solvent was evaporated under reduced pressure and the residue was washed with ether and dissolved in water. The basic solution was acidified with dilute hydrochloric acid and extracted with ether. The ether layer was extracted with dilute sodium bicarbonate solution. The aqueous solution was re-acidified with dilute hydrochloric acid and extracted with ether. The ether extract was dried (Na2SO4) and concentrated under reduced pressure. The residue was crystallized from ethanol to give 5-phenyl-2-benzofurancarboxylic acid (1C), as white solid, mp: 220°-221° C.

1. temperaturewas refluxed for 4 hours
2. customThe solvent was evaporated under reduced pressure
3. washthe residue was washed with ether
4. dissolutiondissolved in water
5. extractionextracted with ether
6. extractionThe ether layer was extracted with dilute sodium bicarbonate solution
7. extractionextracted with ether
8. extractionThe ether extract
9. dry with materialwas dried (Na2SO4)
10. concentrationconcentrated under reduced pressure
11. customThe residue was crystallized from ethanol