Ethanol → HCID 18347834, compound

Participants

Reaction Steps

A mixture of crude ethyl di-(4-chlorophenyl)methyloxyacetate (9 g.), sodium hydroxide (5 g.), ethanol (150 ml.) and water (5 ml.) was heated under reflux for 16 hours. The mixture was evaporated and the residue was diluted with water (100 ml.) and ether (30 ml.). The ether extracts were discarded and the aqueous phase was acidified to pH 2-3 with 20% v/v hydrochloric acid. The mixture was extracted with ether and the extracts were dried (MgSO4) and evaporated. The residual solid obtained was crystallised from a mixture of ethyl acetate and petrol to give di-(4-chlorophenyl)methyloxyacetic acid, m.p. 108°-110°, in 64% yield.

Provenance & Evidence