Ethanol → HCID 20338040, compound

Participants

Reaction Steps

The mixture of 100 mg of 2-(5,6-dihydro-6-oxo benzo[b]-pyrido[3,2-f]thiepin-9-yl)-propionamide, 170 mg of potassium hydroxide, 1.5 ml of water and 3 ml of ethanol was refluxed for 5 hours. After cooling, the solvent was distilled off to obtain the residue, to which was added ice-water and the resulting mixture was acidified with acetic acid and extracted with chloroform. The extract was washed with water and dried over anhydrous sodium sulfate. The solvent was distilled off to obtain the solid substance, which was recrystallized from benzene to give 70 mg of 2-(5,6-dihydro-6-oxo benzo[b]pyrido-[3,2-f]thiepin-9-yl)-propionic acid as pale yellow powder having a melting point of 150°-151° C.

Provenance & Evidence