Potassium 3-(N-acetylglycyl)dithiocarbazate → HCID 178474654, compound

HRID 1395779Notes

Reaction equation

HRID 1395779 reaction equation
[C:1]([NH:4][CH2:5][C:6]([NH:8][NH:9][C:10]([S-:12])=[S:11])=O)(=[O:3])[CH3:2].[K+]>S(=O)(=O)(O)O>[C:1]([NH:4][CH2:5][C:6]1[S:11][C:10]([SH:12])=[N:9][N:8]=1)(=[O:3])[CH3:2]

Participants

3

Reactant 1

HCID 23686815Potassium 3-(N-acetylglycyl)dithiocarbazate

Product 1

HCID 178474654HCID 178474654, compoundYield 69.1%

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

Potassium 3-(N-acetylglycyl)dithiocarbazate (102.3 g) was added bit by bit to concd. sulfuric acid (1 liter) at 0° to 5° C. and the mixture was stirred for an hour at the same temperature. The reaction mixture was added dropwise on crushed ice (c.a. 10 kg) under stirring. Precipitating crystals were collected by filtration to give 5-acetamidomethyl-1,3,4-thiadiazole-2-thiol (54.5 g). m.p. 200° to 203° C.

Workup

  1. additionThe reaction mixture was added dropwise
  2. customPrecipitating crystals
  3. filtrationwere collected by filtration

Sources & evidence

ORD record
ord-8f76d54973da4076a75272e77021934a
Source dataset
uspto-grants-1980_05
Patent number
US04205166

Reaction notes

Loading…