Hydrochloric Acid → HCID 178448347, compound

Participants

Reaction Steps

10.0 g of t-butoxycarbonylsarcosylnitroarginylvalyltyrosine methyl ester is dissolved in 30 ml of methanol. To this solution is added 60 ml of 1 N lithium hydroxide. The reaction mixture is stirred for three hours, then neutralized with 1 N hydrochloric acid to pH 7. The solvent is removed by vacuum and the residue is dissolved in N,N-dimethylformamide. The solution is filtered and the solvent removed by vacuum. The residue is dissolved in methanol/2-propanol. The alcohol solution is added to 1 liter of cold rapidly stirring ethyl ether. The white precipitate is filtered and dried in vacuo to afford t-butoxycarbonylsarcosylnitroarginylvalyltyrosine.

Provenance & Evidence