HuagongsheHuagongshe Chemistry Print Report · For research reference only
Adipic Acid → Ivabradine adipate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Adipic Acid | HCID 196 | — |
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Ivabradine | HCID 132999 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Ivabradine adipate | HCID 86680271 | — |
Reaction Steps
Ivabradine adipate can be obtained by adding adipic acid, e.g. about one equivalent, in a suitable solvent, such as ethanol, to a solution of ivabradine in a suitable solvent, such as dichloromethane. Crystalline ivabradine adipate product can be obtained by removal of the solvent, e.g. under vacuum at about 40° C. Crystalline ivabradine adipate can also be obtained by adding a solution of adipic acid in water to a solution of ivabradine in ethanol, and removal of the solvent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08900605B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-af906227052d4097b1741e0d97e6fcb8 |
| Source note | uspto-grants-2014_12 |