反应详情

The solid from above which contained sodium 4-hydroxy-1,1,2,2-tetrafluorobutane-1-sulfonate was extracted with methanol (100 mL) and filtered. The resulting pale yellow solution was passed through a short column (2.5 cm diameter) which was packed with 7.5 cm of Amberlite 120H acid ion exchange resin to give a light brown solution. Additional methanol was used to flush any remaining sulfonic acid. The volatiles were removed under reduced pressure to give a dark brown oil. The yield was 15.453 g, 77% based on starting 4-bromo-3,3,4,4-tetrafluoro-1-butanol.

1. extractionwas extracted with methanol (100 mL)
2. filtrationfiltered
3. customto give a light brown solution
4. customto flush any remaining sulfonic acid
5. customThe volatiles were removed under reduced pressure
6. customto give a dark brown oil