Sodium Hydroxide → HCID 178484382, compound

N,N-dimethylimidodicarbonimidic diamide hydrochloride (4.01 g, 24.3 mmol) was dissolved in 1N sodium hydroxide (24.2 mL, 24.2 mmol) and stirred at room temperature for 30 minutes. The solution was concentrated in vacuo and to the residue was added ethanol (80 mL). The mixture was carefully concentrated to azeotropically remove water. To the resulting solid was added EtOH (60 mL) and the suspension was filtered to remove precipitated NaCl. The filtrate was concentrated and the resulting solid was placed on high vacuum overnight to yield 3.18 g (102%) of metformin as a white solid.

1. concentrationThe solution was concentrated in vacuo and to the residue
2. additionwas added ethanol (80 mL)
3. concentrationThe mixture was carefully concentrated to azeotropically remove water
4. additionTo the resulting solid was added EtOH (60 mL)
5. filtrationthe suspension was filtered
6. customto remove
7. customprecipitated NaCl
8. concentrationThe filtrate was concentrated
9. customwas placed on high vacuum overnight

ORD record

ord-aec1b8b5fe0147e0a4288a4c1aca0f9a

Source dataset

uspto-grants-2014_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08901107B2