反应详情

10 g of p-toluamide were suspended in 100 ml of ether and 12.5 ml of pyridine under argon. The 5.8 ml of thionyl chloride dissolved in 10 ml of ether were added dropwise at 5° C. and the mixture was stirred for a further 5 minutes. Subsequently, the cooling was removed and the mixture was stirred at room temperature for a further 16 hours. Under argon, the solid pyridinium hydrochloride was then filtered off, and then the solution was concentrated. The residue was used without further workup.

1. additionwere added dropwise at 5° C.
2. customSubsequently, the cooling was removed
3. stirringthe mixture was stirred at room temperature for a further 16 hours
4. filtrationUnder argon, the solid pyridinium hydrochloride was then filtered off
5. concentrationthe solution was concentrated