HCID 58134770、化合物 → 1-Amino-1-(2-hydroxypropan-1-yl)cyclobutane

HRID 1396106ノート

反応式

HRID 1396106 の反応式
C([NH:8][C:9]1([CH2:13][CH:14]([OH:16])[CH3:15])[CH2:12][CH2:11][CH2:10]1)C1C=CC=CC=1>CCO.[Pd]>[NH2:8][C:9]1([CH2:13][CH:14]([OH:16])[CH3:15])[CH2:12][CH2:11][CH2:10]1

参加物

4

反応物 1

HCID 58134770HCID 58134770、化合物

生成物 1

HCID 552844011-Amino-1-(2-hydroxypropan-1-yl)cyclobutane収率 94.1%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

10% Pd—C (300 mg) was added to a solution of 1-[1-(benzylamino)cyclobutyl]-2-propanol (2.24 g, 10.2 mmol) in EtOH (50 mL) and the mixture was stirred under H2 gas (5 kgf/cm2) at room temperature for 10 hours. The mixture was filtered and the filtrate was concentrated in vacuo. Distillation of the residue gave the title compound as a pale yellow oil (1.24 g, 94%).

後処理

  1. filtrationThe mixture was filtered
  2. concentrationthe filtrate was concentrated in vacuo
  3. distillationDistillation of the residue

出典と根拠

ORDレコード
ord-e549e26666774c1d9e59531e4e6cfe84
出典データセット
uspto-grants-2014_12
特許番号
US08901112B2

反応ノート

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