4-((4-Methylpiperazin-1-yl)methyl)aniline → HCID 70687738, compound

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The title compound was prepared according to synthesis procedure B described above from 2-chloro-4-(3-chloro-4-fluorophenoxy)-5-methylpyrimidine and 4-((4-methylpiperazin-1-yl)methyl)aniline in 59% yield (yellow solid) after flash chromatography (CH2Cl2/CH3OH 99:1 gradually increasing to 95:5). 1H NMR (400 MHz, CDCl3): δ H 8.10 (s, 1H), 7.43 (t, 1H, J=8.4 Hz), 7.23 (d, 2H), 7.09 (d, 2H, J=8.2 Hz), 7.04 (dd, 1H, J=9.6, 2.4 Hz), 6.94 (m, 1H), 3.42 (s, 2H), 2.46 (bs, 8H) 2.27 (s, 3H), 2.18 (s, 3H); MS (ESI): 442.3 [M+H]+, 221.7 [M+2H]2+.

Provenance & Evidence