4-((4-Methylpiperazin-1-yl)methyl)aniline → HCID 66576868, compound

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The title compound was prepared according to synthesis procedure B described above from 2-chloro-5-methyl-4-(3-(trifluoromethoxy)phenyl)pyrimidine and 4-((4-methylpiperazin-1-yl)methyl)aniline in 79% yield (yellow solid) after flash chromatography (CH2Cl2/CH3OH 99:1 gradually increasing to 95:5). 1H NMR (400 MHz, CDCl3): δ 8.32 (s, 1H), 7.57 (d, 3H, J=8.5 Hz), 7.52 (s, 1H), 7.50 (t, 1H, J=7.9 Hz), 7.29 (d, 1H, J=7.9 Hz), 7.25 (d, 2H, J: not calculated due to overlapping peaks), 3.45 (s, 2H), 2.47 (bs, 8H), 2.28 (s, 3H), 2.26 (s, 3H); MS (ESI): 458.3 [M+H]+, 229.7 [M+2H]2+.

Provenance & Evidence