4-((4-Methylpiperazin-1-yl)methyl)aniline → HCID 66576872, compound

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The title compound was prepared according to synthesis procedure B described above from 2-chloro-4-(3-methoxyphenyl)-5-methylpyrimidine and 4-((4-methylpiperazin-1-yl)methyl)aniline in 20% yield (yellow solid) after flash chromatography (CH2Cl2/CH3OH 99:1 gradually increasing to 95:5). 1H NMR (400 MHz, CDCl3): δ 8.29 (s, 1H), 7.59 (d, 2H, J=8.2 Hz), 7.37 (t, 1H, J=8.0 Hz), 7.24 (d, 2H, J: not calculated due to overlapping peaks), 7.16 (m, 2H), 6.98 (d, 1H, J=8.2 Hz), 3.85 (s, 3H), 3.49 (s, 2H), 2.57 (bs, 8H), 2.36 (s, 3H), 2.24 (s, 3H); MS (ESI): 404.4 [M+H]+, 202.9 [M+2H]2+.

Provenance & Evidence