反应详情

Treatment of (−)-benzyl (5-methyl-3,6,7,8-tetrahydro-2H-indeno[4,5-b]furan-2-yl)methylcarbamate (1.39 g, 4.12 mmol) with palladium on carbon (10 wt. %, 0.139 g) generally according to the procedure described for Example 2 afforded 0.862 g (87%) of (−)-1-(3,6,7,8-tetrahydro-2H-indeno[4,5-b]furan-2-yl)methanamine as a white solid, hydrochloride salt. [α]D25=+48.6 (c 10.0 in methanol); mp>220° C.; Anal. calcd. for C13H17NOHCl.0.1H2O: C, 64.64; H, 7.59; N, 5.80. Found: C, 64.62; H, 7.66; N, 5.77.