4-((4-Methylpiperazin-1-yl)methyl)aniline → HCID 70685607, compound

Participants

Reaction Steps

The title compound was prepared according to synthesis procedure B described above from 4-((2,5-dichloropyrimidin-4-yl)amino)-3-(pyrrolidin-1-ylsulfonyl)phenol and 4-((4-methylpiperazin-1-yl)methyl)aniline in 27% yield (yellow solid) after flash chromatography (CH2Cl2/CH3OH 99:1 gradually increasing to 95:5). 1H NMR (400 MHz, CDCl3): δ 8.08 (s, 1H), 7.87 (d, 1H, J=8.4 Hz), 7.67 (s, 1H), 7.44 (d, 2H, J=8.1 Hz), 7.26 (1H), 7.23 (d, 2H, J=8.4 Hz), 7.10 (d, 1H, J=8.8 Hz), 3.53 (s, 2H), 3.33 (m, 4H), 2.63 (bs, 8H), 2.43 (s, 3H), 1.83 (m, 4H); MS (ESI): 558.1 [M+H]+.

Provenance & Evidence