Ammonia → 6-Chloro-4-(6-[1,2,3]triazol-1-yl-pyridin-2-ylamino)-pyridazine-3-carboxylic acid amide

HRID 1396338노트

반응식

HRID 1396338 반응식
C([O:3][C:4]([C:6]1[N:7]=[N:8][C:9]([Cl:24])=[CH:10][C:11]=1[NH:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([N:19]2[CH:23]=[CH:22][N:21]=[N:20]2)[N:14]=1)=O)C.[NH3:25]>CO>[Cl:24][C:9]1[N:8]=[N:7][C:6]([C:4]([NH2:25])=[O:3])=[C:11]([NH:12][C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([N:19]3[CH:23]=[CH:22][N:21]=[N:20]3)[N:14]=2)[CH:10]=1

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 866897086-Chloro-4-(6-[1,2,3]triazol-1-yl-pyridin-2-ylamino)-pyridazine-3-carboxylic acid ethyl ester

생성물 1

HCID 866897096-Chloro-4-(6-[1,2,3]triazol-1-yl-pyridin-2-ylamino)-pyridazine-3-carboxylic acid amide수율 100%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

6-Chloro-4-(6-[1,2,3]triazol-1-yl-pyridin-2-ylamino)-pyridazine-3-carboxylic acid ethyl ester (48 mg, 0.139 mmol) was suspended in 7M ammonia in methanol (23 mL). After 4 h, the reaction mixture was concentrated in vacuo to give 6-chloro-4-(6-[1,2,3]triazol-1-yl-pyridin-2-ylamino)-pyridazine-3-carboxylic acid amide (44 mg, 100%) as an off-white solid which was used directly in the next step without purification. MS (EI/CI) m/z: 317 [M+H].

후처리

  1. concentrationthe reaction mixture was concentrated in vacuo

출처 및 근거

ORD 기록
ord-bf655eacbbf5406d8d04b05939f868d8
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08901124B2

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