1H-Pyrrolo(2,3-b)pyridine → HCID 178526243, compound

Participants

Reaction Conditions

Reaction Steps

1H-pyrrolo[2,3-b]pyridine (2.8 g, 24 mmol) was dissolved in ethyl acetate (24 mL) and cooled to 0° C. A solution of 3-chloroperbenzoic acid (77%, 6.7 g, 30.1 mmol) in ethyl acetate (24 mL) was added drop-wise then the reaction mixture warmed to 25° C. over 16 h. The reaction mixture was cooled to 0° C., filtered, and the solids dried to give crude 1H-pyrrolo[2,3-b]pyridine 7-oxide, 3-chlorobenzoic acid complex (4.1 g, 58%) as an off-white solid. This was used directly in the next step without purification. LCMS (EI/CI) m/z: 135 [M+H].

Provenance & Evidence