反应详情

In a 50 mL round bottom flask, ethyl 6-chloro-4-(5,6-dimethylpyridin-2-ylamino)pyridazine-3-carboxylate (929 mg, 3.03 mmol) was suspended in ammonia 7M in methanol (7.87 g, 10.0 mL, 70.0 mmol). The flask was sealed and stirred for 2 h at room temperature. Solvents evaporated and solid residue dried in high vacuum to give 6-chloro-4-(5,6-dimethylpyridin-2-ylamino)pyridazine-3-carboxamide (841 mg, 100% yield) as an off-white solid. 1H NMR (CHLOROFORM-d) δ: 11.37 (br. s., 1H), 9.11 (s, 1H), 8.09 (br. s., 1H), 7.32 (d, J=8.3 Hz, 1H), 6.63 (d, J=8.1 Hz, 1H), 5.59 (br. s., 1H), 2.43 (s, 3H), 2.19 (s, 3H); LC-MS 278.0 [M+H]+.

1. customThe flask was sealed
2. customSolvents evaporated
3. customsolid residue dried in high vacuum