反应详情

温度

35 °C

Ammonia in methanol (3.94 g, 5 mL, 35.0 mmol) was added to ethyl 4-(6-(2H-1,2,3-triazol-2-yl)pyridin-2-ylamino)-6-chloropyridazine-3-carboxylate (100 mg, 289 μmol) and stirred at 35° C. for 16 h. The mixture was concentrated in vacuo to give 4-(6-(2H-1,2,3-triazol-2-yl)pyridin-2-ylamino)-6-chloropyridazine-3-carboxamide (90 mg, 284 μmol, 98%) as an off-white solid. 1H NMR (400 MHz, DMSO-d) δ ppm 12.30 (s, 1H), 9.13 (s, 1H), 9.54 (s, 1H), 8.94 (s, 1H), 8.29 (s, 1H), 8.27 (s, 2H), 8.05 (t, J=8.1 Hz, 1H), 7.72 (d, J=7.9 Hz, 1H), 7.23 (d, J=8.1 Hz, 1H); MS (EI/CI) m/z: 316.9 [M+H].

1. concentrationThe mixture was concentrated in vacuo