Acetone → Ethyl 6-chloro-4-(6-propylpyridin-2-ylamino)pyridazine-3-carboxylate

HRID 1396418Notes

Reaction equation

Cl[C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[N:4][C:3]=1[C:9]([O:11][CH2:12][CH3:13])=[O:10].[CH2:14]([C:17]1[N:22]=[C:21]([NH2:23])[CH:20]=[CH:19][CH:18]=1)[CH2:15][CH3:16].CC(C)=O>C(#N)C.ClCCl>[Cl:8][C:6]1[N:5]=[N:4][C:3]([C:9]([O:11][CH2:12][CH3:13])=[O:10])=[C:2]([NH:23][C:21]2[CH:20]=[CH:19][CH:18]=[C:17]([CH2:14][CH2:15][CH3:16])[N:22]=2)[CH:7]=1

Participants

Conditions

Temperature: 130 °C

Procedure

A mixture of ethyl 4,6-dichloropyridazine-3-carboxylate (0.80 g, 3.62 mmol) and 6-propylpyridin-2-amine (739 mg, 5.43 mmol) was dissolved in acetonitrile (4 mL) and heated at 130° C. After 24 h, the reaction mixture was cooled and concentrated in vacuo, then purified by chromatography (silica, 80 g, 0 to 3% acetone in dichloromethane over 15 min, then 3 to 10% acetone in dichloromethane over another 15 min) to give ethyl 6-chloro-4-(6-propylpyridin-2-ylamino)pyridazine-3-carboxylate (335 mg, 1.04 mmol, 29%) as a pale yellow crystalline solid after drying under high vacuum at room temperature. LC-MS 321.1 [M+H]+.

Workup

temperaturethe reaction mixture was cooled
concentrationconcentrated in vacuo
custompurified by chromatography (silica, 80 g, 0 to 3% acetone in dichloromethane over 15 min

Sources & evidence

ORD record: ord-ed07ed0d6e5f4ee49b15b055c433de28
Source dataset: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08901124B2

Reaction notes

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