Ammonia → 6-Chloro-4-(6-propylpyridin-2-ylamino)pyridazine-3-carboxamide

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Reaction Steps

Ethyl 6-chloro-4-(6-propylpyridin-2-ylamino)pyridazine-3-carboxylate (340 mg, 1.06 mmol) was stirred with 7N methanolic ammonia (15.1 mL, 106 mmol). A colorless precipitate formed within a few minutes. After 18 h, the mixture was concentrated in vacuo to give 6-chloro-4-(6-propylpyridin-2-ylamino)pyridazine-3-carboxamide (289 mg, 991 μmol, 94%) as an off-white powder. LC-MS 292.2 [M+H]+. This material was used directly without further purification.

Provenance & Evidence