反应详情

温度

25 °C

To a solution of ethyl 4-(6-(1H-pyrazol-1-yl)pyridin-2-ylamino)-6-chloropyridazine-3-carboxylate (107 mg of ˜83% purity, 258 μmol) in methanol (1 mL) was added ammonia in methanol (2.5 mL, 17.5 mmol) and the mixture warmed at 25° C. for 18 h. The mixture was cooled, filtered, and the collected solid dried in vacuo to give 4-(6-(1H-pyrazol-1-yl)pyridin-2-ylamino)-6-chloropyridazine-3-carboxamide (45 mg, 141 μmol, 55%) as a white solid.

1. temperatureThe mixture was cooled
2. filtrationfiltered
3. customthe collected solid dried in vacuo