Ammonia → 4-(6-(1H-pyrazol-1-yl)pyridin-2-ylamino)-6-chloropyridazine-3-carboxamide

HRID 1396446노트

반응식

HRID 1396446 반응식
[N:1]1([C:6]2[N:11]=[C:10]([NH:12][C:13]3[CH:18]=[C:17]([Cl:19])[N:16]=[N:15][C:14]=3[C:20]([O:22]CC)=O)[CH:9]=[CH:8][CH:7]=2)[CH:5]=[CH:4][CH:3]=[N:2]1.[NH3:25]>CO>[N:1]1([C:6]2[N:11]=[C:10]([NH:12][C:13]3[CH:18]=[C:17]([Cl:19])[N:16]=[N:15][C:14]=3[C:20]([NH2:25])=[O:22])[CH:9]=[CH:8][CH:7]=2)[CH:5]=[CH:4][CH:3]=[N:2]1

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 86689786ethyl 4-(6-(1H-pyrazol-1-yl)pyridin-2-ylamino)-6-chloropyridazine-3-carboxylate

생성물 1

HCID 866897874-(6-(1H-pyrazol-1-yl)pyridin-2-ylamino)-6-chloropyridazine-3-carboxamide수율 55%

시약·촉매·용매 1

HCID 887Methanol용매2회

반응 조건

온도
25 °C

실험 절차

To a solution of ethyl 4-(6-(1H-pyrazol-1-yl)pyridin-2-ylamino)-6-chloropyridazine-3-carboxylate (107 mg of ˜83% purity, 258 μmol) in methanol (1 mL) was added ammonia in methanol (2.5 mL, 17.5 mmol) and the mixture warmed at 25° C. for 18 h. The mixture was cooled, filtered, and the collected solid dried in vacuo to give 4-(6-(1H-pyrazol-1-yl)pyridin-2-ylamino)-6-chloropyridazine-3-carboxamide (45 mg, 141 μmol, 55%) as a white solid.

후처리

  1. temperatureThe mixture was cooled
  2. filtrationfiltered
  3. customthe collected solid dried in vacuo

출처 및 근거

ORD 기록
ord-9a85db8e21234af7b87a5c3b126edccc
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08901124B2

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