Sodium chloride; water → HCID 89675036, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 6-chloro-4-(6-isopropyl-5-methoxypyridin-2-ylamino)pyridazine-3-carboxamide (199 mg, 618 μmol, prepared as described in example 32) in NMP (2.06 mL) was added tert-butyl (3R,4R)-4-aminotetrahydro-2H-pyran-3-ylcarbamate (536 mg, 2.47 mmol) in four portions approximately every 12 h and the mixture heated at 140° C. After 48 h total heating time the mixture was cooled and then diluted with ethyl acetate and brine. The phases were separated then the organic phase was washed with brine (2×), then concentrated in vacuo and the residue obtained was purified by chromatography (silica, 10 to 50% methanol in dichloromethane) to give 6-chloro-4-(6-isopropyl-5-methoxypyridin-2-ylamino)pyridazine-3-carboxamide (199 mg, 618 μmol, quantitative) as a light brown solid. MS (EI/CI) m/z: 502.2 [M+H].

Provenance & Evidence