Ammonia → HCID 86689791, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of ethyl 6-chloro-4-(6-isopropyl-4-methylpyridin-2-ylamino)pyridazine-3-carboxylate (115 mg, 343 μmol) in methanol (1 mL) was added ammonia in methanol (7 N, 4.91 mL, 34.3 mmol) and then the mixture heated at 45° C. for 20 h. The mixture was concentrated in vacuo to give 6-chloro-4-(6-isopropyl-4-methylpyridin-2-ylamino)pyridazine-3-carboxamide (105 mg, 343 μmol, 100%) as a white solid. 1H NMR (400 MHz, DMSO-d6) δ ppm 11.91 (s, 1H), 9.25 (s, 1H), 8.85 (s, 1H), 8.21 (s, 1H), 6.87 (s, 1H), 6.77 (s, 1H), 3.01 (m, 1H), 2.31 (s, 3H), 1.28 (d, J=6.6 Hz, 6H); MS (EI/CI) m/z: 305.9 [M+H].

Provenance & Evidence