Potassium Carbonate → HCID 68978422, compound

Participants

Reaction Steps

4-(6-Amino-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-bromo-6-fluoro-phenol hydrochloride (Example 42b) (30 mg, 0.08 mmol) is dissolved in anhydrous THF (10 ml), K2CO3 (12 mg, 0.09 mmol) is added and the reaction mixture is stirred at room temperature for 10 minutes. Triphenylphosphine (116 mg, 0.44 mmol), DIAD (0.076 ml, 0.40 mmol) and 1-(2-hydroxyethyl)pyrrolidine (0.048 ml, 0.40 mmol) are added and the reaction mixture is heated to reflux for 20 hours. After cooling to room temperature the reaction mixture is diluted with water (˜15 ml) and extracted with EtOAc (3×50 ml). The combined organic portions are dried over MgSO4, filtered and concentrated in vacuo Purification of the crude residue by flash chromatography on silica firstly eluting the non-polar impurities with iso-hexanes:EtOAc (4:1 to 1:4) then eluting the product with EtOAc:MeOH:Et3N (4:1:0.01) affords the title compound.

Provenance & Evidence