HCID 68960591, compound → HCID 136387220, compound

HRID 1396551Notes

Reaction equation

HRID 1396551 reaction equation
C[O:2][C:3]1[CH:8]=[C:7]([O:9]C)[CH:6]=[CH:5][C:4]=1[C:11]1[C:19]2[C:14](=[N:15][C:16]([NH2:20])=[N:17][CH:18]=2)[N:13]([CH3:21])[N:12]=1>O>[NH2:20][C:16]1[N:15]=[C:14]2[N:13]([CH3:21])[N:12]=[C:11]([C:4]3[CH:5]=[CH:6][C:7]([OH:9])=[CH:8][C:3]=3[OH:2])[C:19]2=[CH:18][N:17]=1

Participants

3

Reactant 1

HCID 68960591HCID 68960591, compound

Product 1

HCID 136387220HCID 136387220, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

This compound is prepared analogously to Example 91 by replacing 3-(2-Methoxy-5-trifluoromethyl-phenyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-6-ylamine phenyl) (Example 88) with 3-(2,4-Dimethoxy-phenyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-6-ylamine (Example 89). The addition of water during the aqueous quench results in a precipitate but on filtration a gum forms, this gum is therefore triturated with diethyl ether (50 ml) to form a solid, which is collected by filtration and dried under vacuum to afford the title compound.

Workup

  1. customThis compound is prepared analogously to Example 91
  2. customaqueous quench
  3. customresults in a precipitate but on filtration a gum forms
  4. customthis gum is therefore triturated with diethyl ether (50 ml)
  5. customto form a solid, which
  6. filtrationis collected by filtration
  7. customdried under vacuum

Sources & evidence

ORD record
ord-83ffa96f4e6b4b2b9d7e1caf3061a516
Source dataset
uspto-grants-2014_12
Patent number
US08901134B2

Reaction notes

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