HCID 68959286, compound → HCID 136387223, compound

Participants

Reaction Steps

3-(3,5-Difluoro-4-methoxy-phenyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-6-ylamine (Example 98) (0.1 g, 0.342 mmol) is dissolved in 48% HBr in water (5 ml) and heated using microwave radiation at 120° C. for 30 minutes. Purification of the reaction mixture by preparative HPLC (water/acetonitrile, 0.1% TFA) affords the title compound as a white solid.

Provenance & Evidence