Sulfuric Acid → HCID 86630407, compound

HRID 1396561Notes

Reaction equation

HRID 1396561 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[CH:6]=[CH:5][C:4]=1[C:11]1[C:19]2[C:14](=[N:15][C:16]([NH2:20])=[N:17][CH:18]=2)[N:13]([CH3:21])[N:12]=1.[S:22](=O)(=[O:25])([OH:24])[OH:23]>>[NH2:20][C:16]1[N:15]=[C:14]2[N:13]([CH3:21])[N:12]=[C:11]([C:4]3[C:3]([O:2][CH3:1])=[CH:8][C:7]([O:9][CH3:10])=[C:6]([S:22]([OH:25])(=[O:24])=[O:23])[CH:5]=3)[C:19]2=[CH:18][N:17]=1

Participants

3

Reactant 2

HCID 1118Sulfuric AcidHCID 68960591HCID 68960591, compound

Product 1

HCID 86630407HCID 86630407, compound

Procedure

3-(2,4-Dimethoxy-phenyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-6-ylamine (Example 89) (1 g, 3.50 mmol) is dissolved in concentrated sulfuric acid (25 ml) to give a blood red solution. The reaction mixture is stirred at room temperature overnight, poured onto ice-water (200 ml) and the resulting solid is collected by filtration, washed with water and dried under vacuum to afford the title compound.

Workup

  1. customto give a blood red solution
  2. additionpoured onto ice-water (200 ml)
  3. filtrationthe resulting solid is collected by filtration
  4. washwashed with water
  5. customdried under vacuum

Sources & evidence

ORD record
ord-686b1564752e438c88b4ace2e8d72e19
Source dataset
uspto-grants-2014_12
Patent number
US08901134B2

Reaction notes

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