Trichloroisocyanuric Acid → HCID 68967195, compound

HRID 1396562Notes

Reaction equation

HRID 1396562 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[CH:6]=[CH:5][C:4]=1[C:11]1[C:19]2[C:14](=[N:15][C:16]([NH2:20])=[N:17][CH:18]=2)[N:13]([CH3:21])[N:12]=1.[Cl:22]N1C(=O)N(Cl)C(=O)N(Cl)C1=O>C(#N)C>[Cl:22][C:6]1[C:7]([O:9][CH3:10])=[CH:8][C:3]([O:2][CH3:1])=[C:4]([C:11]2[C:19]3[C:14](=[N:15][C:16]([NH2:20])=[N:17][CH:18]=3)[N:13]([CH3:21])[N:12]=2)[CH:5]=1

Participants

4

Reactant 2

HCID 6909Trichloroisocyanuric AcidHCID 68960591HCID 68960591, compound

Product 1

HCID 68967195HCID 68967195, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

3-(2,4-Dimethoxy-phenyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-6-ylamine (Example 89) is suspended in acetonitrile (10 ml), trichloroisocyanuric acid (0.021 g, 0.09 mmol) is added and the reaction mixture is stirred for 1.5 hours at room temperature then stood overnight. The solvents are removed in vacuo, the residue is dissolved in EtOAc, washed with water and brine, dried over MgSO4, filtered, concentrated in vacuo and dried under vacuum (45° C.) to afford the title compound.

Workup

  1. waitthen stood overnight
  2. customThe solvents are removed in vacuo
  3. dissolutionthe residue is dissolved in EtOAc
  4. washwashed with water and brine
  5. dry with materialdried over MgSO4
  6. filtrationfiltered
  7. concentrationconcentrated in vacuo
  8. customdried under vacuum (45° C.)

Sources & evidence

ORD record
ord-939577eefad846739a6d20d04a6c4787
Source dataset
uspto-grants-2014_12
Patent number
US08901134B2

Reaction notes

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