Dichloromethane → HCID 136387225, compound

Participants

Reaction Steps

A mixture of 3-(2-Methoxy-4-trifluoromethoxy-phenyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-6-ylamine (Example 123) (50 mg, 0.147 mmol) and 1M BBr3 in DCM (3 ml, 2.94 mmol) is stirred at room temperature for 30 minutes. The reaction mixture is quenched with water (5 ml) and stirred for a further 30 minutes. The resulting precipitate is collected by filtration, washed with water and dried under vacuum (50° C.) to afford the title compound as the hydrobromide salt.

Provenance & Evidence