Chlorosulfonic acid → HCID 86630408, compound

HRID 1396567Notes

Reaction equation

HRID 1396567 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:16]3[C:11](=[N:12][C:13]([NH2:17])=[N:14][CH:15]=3)[N:10]([CH3:18])[N:9]=2)=[CH:4][CH:3]=1.[Cl:19][S:20](O)(=[O:22])=[O:21]>>[NH2:17][C:13]1[N:12]=[C:11]2[N:10]([CH3:18])[N:9]=[C:8]([C:5]3[CH:6]=[CH:7][C:2]([Cl:1])=[C:3]([S:20]([Cl:19])(=[O:22])=[O:21])[CH:4]=3)[C:16]2=[CH:15][N:14]=1

Participants

3

Reactant 2

HCID 24638Chlorosulfonic acidHCID 68961556HCID 68961556, compound

Product 1

HCID 86630408HCID 86630408, compound

Conditions

Temperature
120 °C

Procedure

3-(4-Chloro-phenyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-6-ylamine (559 mg, 2.15 mmol) is dissolved in chlorosulfonic acid (6.45 ml, 96.84 mmol) and the reaction mixture is heated to 120° C. for 24 hours. After cooling to room temperature the reaction mixture is used crude as a solution for the next step.

Workup

  1. temperatureAfter cooling to room temperature the reaction mixture

Sources & evidence

ORD record
ord-e504b1d3bdd847de812ca0eab5715197
Source dataset
uspto-grants-2014_12
Patent number
US08901134B2

Reaction notes

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