HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Fluoro-4-methoxyphenylboronic acid → N*4*-Benzyl-3-(3-fluoro-4-methoxy-phenyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Fluoro-4-methoxyphenylboronic acid | HCID 2782194 | — |
| Reactant | 3-Bromo-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-6-ylamine | HCID 68962692 | — |
| Reactant | N*4*-Benzyl-3-bromo-1-methyl-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine | HCID 86630411 | — |
| Product | N*4*-Benzyl-3-(3-fluoro-4-methoxy-phenyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine | HCID 57699545 | — |
Reaction Steps
This compound is prepared analogously to Example 88 by replacing 3-Bromo-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-6-ylamine (Intermediate 3) with N*4*-Benzyl-3-bromo-1-methyl-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine (Intermediate 15) and by replacing 2-methoxy-5-trifluoromethylphenylboronic acid with 3-fluoro-4-methoxyphenylboronic acid to afford the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08901134B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-80bedbde13714912842edfc7ede6ad46 |
| Source note | uspto-grants-2014_12 |