4-Bromo-2,6-difluoroanisole → (3,5-Difluoro-4-methoxyphenyl)boronic acid

HRID 1396573Notes

Reaction equation

HRID 1396573 reaction equation
ClC1C=C([B:10]([OH:12])[OH:11])C=C(F)C=1O.Br[C:14]1[CH:15]=[C:16]([F:23])[C:17]([O:21][CH3:22])=[C:18]([F:20])[CH:19]=1>>[F:20][C:18]1[CH:19]=[C:14]([B:10]([OH:12])[OH:11])[CH:15]=[C:16]([F:23])[C:17]=1[O:21][CH3:22]

Participants

3

Reactant 2

HCID 27732874-Bromo-2,6-difluoroanisoleHCID 55273228HCID 55273228, compound

Product 1

HCID 17750046(3,5-Difluoro-4-methoxyphenyl)boronic acid

Procedure

This compound is prepared analogously to Intermediate 8 by replacing 4-Bromo-2-chloro-6-fluoro-phenol with 5-Bromo-1,3-difluoro-2-methoxy-benzene to afford the title compound.

Sources & evidence

ORD record
ord-603ea62678654c41a8a2d68583a04245
Source dataset
uspto-grants-2014_12
Patent number
US08901134B2

Reaction notes

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