反应详情

2-amino-3-trifluoromethylpyridine (0.980 g, 5.92 mmol) is dissolved in CHCl3 (7 ml) and AcOH (5 ml). The reaction mixture is cooled to 0-10° C. (ice-bath) and bromine (0.424 ml, 8.3 mmol) dissolved in CHCl3 is slowly added drop wise. The reaction mixture is stirred at this temperature for 1 hour then allowed to warm room temperature. The solvents are removed in vacuo and the residue is dissolved in EtOAc washing with saturated NaHCO3. The organic portion is dried over MgSO4, filtered and concentrated to afford the title compound.

1. customThe solvents are removed in vacuo
2. dissolutionthe residue is dissolved in EtOAc washing with saturated NaHCO3
3. dry with materialThe organic portion is dried over MgSO4
4. filtrationfiltered
5. concentrationconcentrated