N-bromobutanimide → HCID 178508433, compound

HRID 1396578Notes

Reaction equation

HRID 1396578 reaction equation
[Br:1]N1C(=O)CCC1=O.[Cl:9][C:10]1[N:15]=[C:14]([NH2:16])[N:13]=[C:12]2[NH:17][N:18]=[CH:19][C:11]=12>ClC(Cl)C>[Br:1][C:19]1[C:11]2[C:12](=[N:13][C:14]([NH2:16])=[N:15][C:10]=2[Cl:9])[NH:17][N:18]=1

Participants

4

Reactant 2

HCID 67184N-bromobutanimideHCID 117896254-chloro-1H-pyrazolo[3,4-d]pyrimidin-6-amine

Product 1

HCID 178508433HCID 178508433, compound

Reagents, catalysts & solvents 1

HCID 63651,1-DichloroethaneSolvent

Procedure

N-bromosuccinimide (673 mg, 3.8 mmol) is added to a suspension of 4-Chloro-1H-pyrazolo[3,4-d]pyrimidin-6-ylamine (500 mg, 2.96 mmol) in dichloroethane (30 ml) and heated to reflux overnight. The reaction mixture is cooled to room temperature and the solvent is removed in vacuo. The resulting solid is diluted with water, stirred for 30 minutes at room temperature, then collected by filtration to afford the title compound.

Workup

  1. temperatureheated
  2. temperatureto reflux overnight
  3. customthe solvent is removed in vacuo
  4. additionThe resulting solid is diluted with water
  5. filtrationcollected by filtration

Sources & evidence

ORD record
ord-79c486b17be94623bbc0af29c938bccd
Source dataset
uspto-grants-2014_12
Patent number
US08901134B2

Reaction notes

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