5-Fluoro-2-nitrophenol → HCID 86718459, compound

Participants

Reaction Conditions

Reaction Steps

To 6.0 g (25.2 mmol) (3R,3aR,6R,6aR)-6-benzyloxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-ol, 3.3 g (21 mmol) 5-fluoro-2-nitro-phenol and 8.3 g (31.5 mmol) triphenyl phosphine in 150 ml THF 7.3 g (31.5 mml) di-tert-butyl azodicarboxylate in 30 ml THF are added dropwise and the reaction mixture is stirred at 40° C. for 2 h. The reaction mixture is evaporated and the residue is purified by FC.

Provenance & Evidence