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HRID1396642

反应详情

EQUATION

反应方程式

HRID 1396642 的结构方程式

REACTANTS

反应物

3
结构：[Cl-].[NH4+]
HCID25517

未命名化合物

结构：O=C1CO[C@H]2[C@@H]1OC[C@H]2Oc1cc(F)ccc1[N+](=O)[O-]
HCID86718460

未命名化合物

结构：[Li]C
HCID178418348

未命名化合物

PRODUCTS

生成物

1
结构：C[C@@]1(O)CO[C@@H]2[C@H](Oc3cc(F)ccc3[N+](=O)[O-])CO[C@@H]21
HCID86718462

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CCOCC
溶剂HCID3283

Diethyl Ether

C4H10O

2 次

结构：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

1.6 g (5.7 mmol) (3R,3aR,6aS)-3-(5-fluoro-2-nitro-phenoxy)-2,3,3a,6a-tetrahydrofuro[3,2-b]furan-6-one (III.7) in THF are cooled to −70° C. 3.5 ml (5.7 mmol) 1.6 mol/l methyl lithium in diethyl ether are added dropwise and the reaction mixture is allowed to reach RT and stirred for 2.5 h. Aqueous NH4Cl solution and diethyl ether are added and the organic layer is separated, dried and evaporated. The residue is purified by FC (Al2O3).

WORKUP

后处理

  1. customto reach RT
  2. customthe organic layer is separated
  3. customdried
  4. customevaporated
  5. customThe residue is purified by FC (Al2O3)