1,1'-Carbonyldiimidazole → HCID 66696247, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 6.00 g of methyl 5-amino-2-(methoxymethyl)-4-[2-(tetrahydrofuran-3-yl)-1H-imidazol-1-yl]benzoate, 5.87 g of 1,1′-carbonyldiimidazole, and 30 mL of 1,2-dichlorobenzene was stirred at 120° C. for 3 hours. After air-cooling, the precipitate was collected by filtration. The obtained solid was washed with methanol and air-dried to obtain 4.54 g of methyl 8-(methoxymethyl)-4-oxo-1-(tetrahydrofuran-3-yl)-4,5-dihydroimidazo[1,5-a]quinoxaline-7-carboxylate.

Provenance & Evidence