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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1396689Generated: October 25, 2026

3-(4-Fluorophenoxy)propionic acid → Dimethyl 2-(3-(4-fluorophenoxy)propanamido)malonate

https://huagongshe.com/reaction/1396689

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(4-Fluorophenoxy)propionic acidHCID 74099—
ReactantDimethyl aminomalonate hydrochlorideHCID 437601—
ProductDimethyl 2-(3-(4-fluorophenoxy)propanamido)malonateHCID 5094157680%

Reaction Steps

This compound was synthesized from dimethyl aminomalonate according to the procedure for the preparation of example 2 using 3-(4-fluorophenoxy)propionic acid. The crude residue was purified by flash chromatography on silica (CH2Cl2/MeOH 50:1) to yield the title compound as a white solid (80%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08901132B2
Source datasetuspto-grants-2014_12
ORD IDord-65a150ca252845d0888cf704465dbc65
Source noteuspto-grants-2014_12