4-Methoxyphenoxyacetic acid → 1-(4-(2-(4-Fluorophenethyl)thiazolo[5,4-d]pyrimidin-7-yl)piperazin-1-yl)-2-(4-methoxyphenoxy)ethanone

HRID 1396779Notes

Reaction equation

HRID 1396779 reaction equation
[F:1][C:2]1[CH:24]=[CH:23][C:5]([CH2:6][CH2:7][C:8]2[S:9][C:10]3[N:11]=[CH:12][N:13]=[C:14]([N:17]4[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]4)[C:15]=3[N:16]=2)=[CH:4][CH:3]=1.[CH3:25][O:26][C:27]1[CH:37]=[CH:36][C:30]([O:31][CH2:32][C:33](O)=[O:34])=[CH:29][CH:28]=1>>[F:1][C:2]1[CH:24]=[CH:23][C:5]([CH2:6][CH2:7][C:8]2[S:9][C:10]3[N:11]=[CH:12][N:13]=[C:14]([N:17]4[CH2:22][CH2:21][N:20]([C:33](=[O:34])[CH2:32][O:31][C:30]5[CH:36]=[CH:37][C:27]([O:26][CH3:25])=[CH:28][CH:29]=5)[CH2:19][CH2:18]4)[C:15]=3[N:16]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 746494-Methoxyphenoxyacetic acidHCID 667589612-(4-Fluorophenethyl)-7-(piperazin-1-yl)thiazolo[5,4-d]pyrimidine

Product 1

HCID 667591041-(4-(2-(4-Fluorophenethyl)thiazolo[5,4-d]pyrimidin-7-yl)piperazin-1-yl)-2-(4-methoxyphenoxy)ethanoneYield 39%

Procedure

This compound was prepared from 2-(4-fluorophenethyl)-7-(piperazin-1-yl)thiazolo[5,4-d]pyrimidine using 4-methoxyphenoxyacetic acid in a yield of 39%, according to the procedure for the synthesis of example 50.

Workup

  1. customaccording to the procedure for the synthesis of example 50

Sources & evidence

ORD record
ord-fdeecdaa3f9d449db85581d1e1950228
Source dataset
uspto-grants-2014_12
Patent number
US08901132B2

Reaction notes

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