反应详情

To a solution of phenylmethyl (3S)-2-[(2R)-3-cyclopentyl-2-({formyl[(phenylmethyl)oxy]amino}methyl)propanoyl]-3-{[(3-methyl-2-pyridinyl)amino]carbonyl}-1-pyrazolidinecarboxylate (179 mg, 0.285 mmol) in methanol (6 ml) was added 20% palladium hydroxide on carbon (72 mg, 0.285 mmol). The mixture was hydrogenated under balloon pressure for 1 h 15 min and then filtered. The mixture was purified by reverse-phase HPLC to yield (3S)-2-((2R)-3-cyclopentyl-2-{[formyl(hydroxy)amino]methyl}propanoyl)-N-(3-methyl-2-pyridinyl)-3-pyrazolidinecarboxamide (44 mg, 0.105 mmol, 37% yield). LC/MS: (M+H)+: 404.

1. filtrationfiltered
2. customThe mixture was purified by reverse-phase HPLC