HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1396908Generated: November 1, 2026
N,N-Dimethyl-1,3-propanediamine → HCID 68287947, compound
https://huagongshe.com/reaction/1396908
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | N,N-Dimethyl-1,3-propanediamine | HCID 7993 | — |
| Reactant | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Reactant | 2-Chloro-4-aminopyrimidine | HCID 345752 | — |
| Product | HCID 68287947 | HCID 68287947 | 57% |
Reaction Steps
A mixture of 2-chloro-4-pyrimidinamine (300 mg, 2.316 mmol), DBU (419 μl, 2.78 mmol) and N,N-dimethyl-1,3-propanediamine (437 μl, 3.47 mmol) was heated to 220° C. via a microwave reactor for 30 min. The reaction mixture was purified by RP-HPLC to yield N2-[3-(dimethylamino) propyl]-2,4-pyrimidinediamine (256 mg, 1.311 mmol, 57% yield). MS (ES+) m/z 196.2 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08901119B2 |
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| Source dataset | uspto-grants-2014_12 |
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| ORD ID | ord-f0dfab811b514b659c2807a39d3fddd5 |
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| Source note | uspto-grants-2014_12 |
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