Acetic Acid → HCID 66546322, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of (3S)-2-((2R)-3-cyclopentyl-2-{[formyl(tetrahydro-2H-pyran-2-yloxy)amino]methyl}propanoyl)-N-2-pyrimidinyl-3-pyrazolidinecarboxamide (20 mg, 0.042 mmol) in the solution of Acetic Acid (2 ml) and Water (0.500 ml) was stirred at 25° C. for overnight. The solvent was removed to give a residue. The residue was purified by RP-HPLC to give (3S)-2-((2R)-3-cyclopentyl-2-{[formyl(hydroxy)amino]methyl}propanoyl)-N-2-pyrimidinyl-3-pyrazolidine carboxamide (9 mg, 0.023 mmol, 54% yield). MS (ES+) m/z 391.3 (MH+).

Provenance & Evidence