HCID 86706369, compound → HCID 66546513, compound

Participants

Reaction Steps

A mixture of phenylmethyl (3S)-2-[(2R)-3-cyclopentyl-2-({formyl[(phenylmethyl)oxy]amino}methyl)propanoyl]-3-[({2-[(dimethylamino)methyl]-4-pyrimidinyl}amino)carbonyl]-1-pyrazolidine carboxylate (104 mg, 0.155 mmol) and Pearlman's catalyst (21.74 mg, 0.031 mmol) in methanol (8.6 ml) was degassed and placed under 1 atm of H2 at ambient temperature. After 2 hrs, the reaction mixture was filtered and concentrated to give a residue which was purified by RP-HPLC to give (3S)-2-((2R)-3-cyclopentyl-2-{[formyl(hydroxy)amino]methyl}propanoyl)-N-{2-[(dimethyl amino)methyl]-4-pyrimidinyl}-3-pyrazolidine carboxamide (41 mg, 0.090 mmol, 58% yield). MS (ES+) m/z 448.2 (MH+).

Provenance & Evidence