HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1396939Generated: October 27, 2026
2-Chloro-4-aminopyrimidine → 2-O-Methylcytosine
https://huagongshe.com/reaction/1396939
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Chloro-4-aminopyrimidine | HCID 345752 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-O-Methylcytosine | HCID 160679 | 50.3% |
Reaction Steps
A mixture of 2-chloro-4-pyrimidinamine (150 mg, 1.158 mmol) and sodium methoxide (188 mg, 3.47 mmol) in methanol (2.9 ml) was heated to 100° C. via a microwave reactor for 40 min. The crude product mixture was purified by RP-HPLC to give 2-(methyloxy)-4-pyrimidinamine (73 mg, 0.583 mmol, 50% yield). MS (ES+) m/z 126.0 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08901119B2 |
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| Source dataset | uspto-grants-2014_12 |
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| ORD ID | ord-c3f8d5c3efa042679a4b7def8999b91a |
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| Source note | uspto-grants-2014_12 |
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