HCID 86706384, compound → HCID 66546695, compound

Participants

Reaction Steps

To a solution of (5S)—N-(5-fluoro-2-pyridinyl)-1-[(2R)-2-({formyl[(phenylmethyl)oxy]amino}methyl)heptanoyl]-4,5-dihydro-1H-pyrazole-5-carboxamide (180 mg, 0.37 mmol) in methanol (15 mL) was added Pd(OH)2/C (105 mg, 20%, 44% wt). The mixture was stirred under a H2 atmosphere for 30 min and the catalyst was filtered off. The filtrate was concentrated and the residue was purified by HPLC to provide the titled compound (70 mg, 48%) as a white solid. LCMS: (M+H)+: 394.2.

Provenance & Evidence