2-(Morpholin-4-yl)pyrimidin-5-amine → HCID 86706387, compound

HRID 1396954Notes

Reaction equation

HRID 1396954 reaction equation
[CH:1]1([CH2:6][C@H:7]([CH2:28][N:29]([CH:38]=[O:39])[O:30]CC2C=CC=CC=2)[C:8]([N:10]2[C@H:14]([C:15]([OH:17])=O)[CH2:13][CH2:12][N:11]2C(OCC2C=CC=CC=2)=O)=[O:9])[CH2:5][CH2:4][CH2:3][CH2:2]1.[N:40]1([C:46]2[N:51]=[CH:50][C:49]([NH2:52])=[CH:48][N:47]=2)[CH2:45][CH2:44][O:43][CH2:42][CH2:41]1>>[CH:1]1([CH2:6][C@H:7]([CH2:28][N:29]([CH:38]=[O:39])[OH:30])[C:8]([N:10]2[C@H:14]([C:15]([NH:52][C:49]3[CH:48]=[N:47][C:46]([N:40]4[CH2:41][CH2:42][O:43][CH2:44][CH2:45]4)=[N:51][CH:50]=3)=[O:17])[CH2:13][CH2:12][NH:11]2)=[O:9])[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

3

Reactant 2

HCID 123954712-(Morpholin-4-yl)pyrimidin-5-amineHCID 86706346(3S)-2-[(2R)-3-cyclopentyl-2-({formyl[(phenylmethyl)oxy]amino}methyl)propanoyl]-1-{[(phenylmethyl)oxy]carbonyl}-3-pyrazolidinecarboxylic acid

Product 1

HCID 86706387HCID 86706387, compound

Procedure

(3S)-2-((2R)-3-Cyclopentyl-2-{[formyl(hydroxy)amino]methyl}propanoyl)-N-[2-(4-morpholinyl)-5-pyrimidinyl]-3-pyrazolidinecarboxamide was prepared according to Example 111, utilizing (3S)-2-[(2R)-3-cyclopentyl-2-({formyl[(phenylmethyl)oxy]amino}methyl)propanoyl]-1-{[(phenylmethyl)oxy]carbonyl}-3-pyrazolidine carboxylic acid in place of (3S)-2-[(2R)-2-({formyl[(phenylmethyl)oxy]amino}methyl)heptanoyl]-1-{[(phenylmethyl)oxy]carbonyl}-3-pyrazolidinecarboxylic acid, and 2-(4-morpholinyl)-5-pyrimidinamine in place of 3-pyridazinamine in part A. LCMS: (M+H)+: 476.0.

Sources & evidence

ORD record
ord-254e7d2a9ec2425da12c6e035374bdd2
Source dataset
uspto-grants-2014_12
Patent number
US08901119B2

Reaction notes

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